• Home
  • Practice Focus
    • Facial Plastic/Reconstructive
    • Head and Neck
    • Laryngology
    • Otology/Neurotology
    • Pediatric
    • Rhinology
    • Sleep Medicine
    • How I Do It
    • TRIO Best Practices
  • Business of Medicine
    • Health Policy
    • Legal Matters
    • Practice Management
    • Tech Talk
    • AI
  • Literature Reviews
    • Facial Plastic/Reconstructive
    • Head and Neck
    • Laryngology
    • Otology/Neurotology
    • Pediatric
    • Rhinology
    • Sleep Medicine
  • Career
    • Medical Education
    • Professional Development
    • Resident Focus
  • ENT Perspectives
    • ENT Expressions
    • Everyday Ethics
    • From TRIO
    • The Great Debate
    • Letter From the Editor
    • Rx: Wellness
    • The Voice
    • Viewpoint
  • TRIO Resources
    • Triological Society
    • The Laryngoscope
    • Laryngoscope Investigative Otolaryngology
    • TRIO Combined Sections Meetings
    • COSM
    • Related Otolaryngology Events
  • Search

Mitochondrial DNA Gene May Be Connected to Allergic Rhinitis

by Amy E. Hamaker • June 17, 2024

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
Print-Friendly Version

CLINICAL QUESTION

Are there associations between allergic rhinitis (AR) and mitochondrial DNA (mtDNA) at a single variant and gene level?

You Might Also Like

  • Intranasal Cryoablation Associated with Positive Outcomes for Management of Refractory Allergic and Non-Allergic Rhinitis
  • Treating Allergic Rhinitis Improves Symptoms of ADHD
  • SCIT Effective for Asthma, Allergic Rhinitis
  • Local Nasal Immunotherapy Safe, Effective for Allergic Rhinitis
Explore This Issue
March 2024

BOTTOM LINE

Mitochondrial gene maps of patients with AR indicated that the ATP6 gene is probably associated with AR at the single-variant level.

BACKGROUND: AR is the most prevalent atopic disease in the world, affecting up to 40% of adults and 25% of children. Although the exact cause of AR is unknown, genetic and environmental interactions play a role in its occurrence. Correlations between mtDNA and AR have not been reported before.

STUDY DESIGN: Cohort study.

SETTING: First Affiliated Hospital of Xinjiang Medical University, Xinjiang, China.

SYNOPSIS: Mitochondrial sequencing was conducted on a total of 134 unrelated individual subjects (68 patients with AR, 66 healthy controls) in the first cohort. Heteroplasmy was analyzed and sequence kernel association tests (SKATs) were conducted to study the association between mitochondrial genes and AR. A single-variant analysis was performed using logistic regression analysis and further validated through 120 subjects in the second cohort (69 patients with AR, 51 healthy controls). Candidate genes were further explored based on differences in mRNA and protein abundance in nasal mucosal tissue. In the first cohort, 886 variants were identified through mitochondrial sequencing. No statistically significant differences were identified for the mitochondrial heteroplasmy or SKAT analysis between these two groups. One of the nonsynonymous variants, rs3135028 (MT8584.G/A) in ATP6, was found to be related to a reduced risk of AR in both the first and second cohorts. In addition, mRNA levels of MT-ATP6 in nasal mucosal tissue were significantly lower in AR individuals than in controls (P < 0.05). Limitations included the small sample size of the expression assay.

CITATION: Yuan H, Wang L, Wang S, et al. Two‑stage association study of mitochondrial DNA variants in allergic rhinitis. Allergy Asthma Clin Immunol. 2024;20:16.

Filed Under: Literature Reviews, Practice Focus, Rhinology, Rhinology Tagged With: ATP6 gene, mtDNAIssue: March 2024

You Might Also Like:

  • Intranasal Cryoablation Associated with Positive Outcomes for Management of Refractory Allergic and Non-Allergic Rhinitis
  • Treating Allergic Rhinitis Improves Symptoms of ADHD
  • SCIT Effective for Asthma, Allergic Rhinitis
  • Local Nasal Immunotherapy Safe, Effective for Allergic Rhinitis

The Triological SocietyENTtoday is a publication of The Triological Society.

Polls

Do you use AI-powered scribes for documentation?

View Results

Loading ... Loading ...
  • Polls Archive

Top Articles for Residents

  • Applications Open for Resident Members of ENTtoday Edit Board
  • How To Provide Helpful Feedback To Residents
  • Call for Resident Bowl Questions
  • New Standardized Otolaryngology Curriculum Launching July 1 Should Be Valuable Resource For Physicians Around The World
  • Do Training Programs Give Otolaryngology Residents the Necessary Tools to Do Productive Research?
  • Popular this Week
  • Most Popular
  • Most Recent
    • The Dramatic Rise in Tongue Tie and Lip Tie Treatment

    • Rating Laryngopharyngeal Reflux Severity: How Do Two Common Instruments Compare?

    • Keeping Watch for Skin Cancers on the Head and Neck

    • Is Middle Ear Pressure Affected by Continuous Positive Airway Pressure Use?

    • Excitement Around Gene Therapy for Hearing Restoration

    • The Dramatic Rise in Tongue Tie and Lip Tie Treatment

    • Rating Laryngopharyngeal Reflux Severity: How Do Two Common Instruments Compare?

    • Is Middle Ear Pressure Affected by Continuous Positive Airway Pressure Use?

    • Otolaryngologists Are Still Debating the Effectiveness of Tongue Tie Treatment

    • Complications for When Physicians Change a Maiden Name

    • The Importance of Time Away
    • Endoscopic Ear Surgery: Advancements and Adoption Challenges 
    • Reflections from a Past President of the Triological Society
    • ENT Surgeons Explore the Benefits and Challenges of AI-Powered Scribes: Revolutionizing Documentation in Healthcare
    • How To: Open Expansion Laryngoplasty for Combined Glottic and Subglottic Stenosis

Follow Us

  • Contact Us
  • About Us
  • Advertise
  • The Triological Society
  • The Laryngoscope
  • Laryngoscope Investigative Otolaryngology
  • Privacy Policy
  • Terms of Use
  • Cookies

Wiley

Copyright © 2025 by John Wiley & Sons, Inc. All rights reserved, including rights for text and data mining and training of artificial technologies or similar technologies. ISSN 1559-4939